Next-Generation Vaccines Based on Bacille Calmette–Guérin
نویسندگان
چکیده
منابع مشابه
Next-Generation Vaccines Based on Bacille Calmette–Guérin
Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb), remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette-Guérin (BCG), derived from the causative agent of cattle TB, Mycobacterium bovis, has been in clinical use as a vaccine for 90 years. The current incidence of TB demonstrates that BCG fails to protect sufficiently ag...
متن کاملCancer vaccines: The next generation
1740-6773/$ 2005 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.ddstr.2005.11.002 Section Editors: Tona Gilmer – GlaxoSmithKline, NC, USA Mike Luzzio – Pfizer Global Research and Development, USA The field of cancer vaccines is as vibrant as ever. Despite pessimism, considerable advances are being made on a regular basis. Success stories continue to be published and newer, exciting and, perh...
متن کاملTuberculosis vaccines: beyond bacille Calmette–Guérin
Tuberculosis (TB) disease caused by Mycobacterium tuberculosis (M. tb) remains one of the leading infectious causes of death and disease throughout the world. The only licensed vaccine, Mycobacterium bovis bacille Calmette-Guérin (BCG) confers highly variable protection against pulmonary disease. An effective vaccination regimen would be the most efficient way to control the epidemic. However, ...
متن کاملVaccine candidate discovery for the next generation of malaria vaccines
Although epidemiological observations, IgG passive transfer studies and experimental infections in humans all support the feasibility of developing highly effective malaria vaccines, the precise antigens that induce protective immunity remain uncertain. Here, we review the methodologies applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to post-genomic era. P...
متن کاملDesigning the next generation of vaccines for global public health.
Vaccine research and development are experiencing a renaissance of interest from the global scientific community. There are four major reasons for this: (1) the lack of efficacious treatment for many devastating infections; (2) the emergence of multidrug resistant bacteria; (3) the need for improving the safety of the more traditional licensed vaccines; and finally, (4) the great promise for in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.00121